MINIMUM margins are:
Top and Left 1" (25 mm)
Right 5/8" (15 mm)
Bottom 3/8" (10 mm)
From How to Make Patent Drawings by Jack Lo and David Pressman:
"Crosshairs, as shown in Illustration 8.2, should be placed at opposite corners of the sight (usable portion of a sheet within the margins) to indicate its boundaries. The centers of the crosshairs should be centered on the corners, so that the outer arms of the crosshairs lie in the margins. The crosshairs can be placed on either the lower-left and upper-right or upper-left and lower-right corners, and should be about 2 cm (3/4") long."
But in Illustration 8.2 they look a lot smaller than this.
Patent It Yourself by David Pressman says they should be about 1.5 cm (0.5") long but also shows them smaller in Fig 10B.
Page number can be put in upper right corner if drawing is too close to center of upper margin.
Avoid landscape orientation whenever possible.